2-氯-4-甲氧基苯乙酸甲酯合成路线 （共 4 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1,2-dichloro-ethane; triethylamine in methanol; n-heptane; dichloromethane; ethyl acetate
参考文献
Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius
Patent: US2010/249139 A1, 2010 ;
US 20100249139 A1
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C;
参考文献
PFIZER INC.
Patent: WO2005/21554 A1, 2005 ;
Location in patent: Page/Page column 69 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius
Patent: US2010/249139 A1, 2010 ;
US 20100249139 A1
反应条件
sulfuric acid
T=0°C; Inert atmosphereReflux;
参考文献
Rousseaux, Sophie; Davi, Michael; Sofack-Kreutzer, Julien; Pierre, Cathleen; Kefalidis, Christos E.; Clot, Eric; Fagnou, Keith; Baudoin, Olivier
Journal of the American Chemical Society, 2010 , vol. 132, # 31 p. 10706 - 10716
