triethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=80°C; 3 h;

1: PdCl2*dppf / 20685.9 Torr 2: HCl / methanol View Scheme

caesium carbonate in toluene T=80°C; 15 h; Sealed tube; Reagent/catalystSolventTemperature;

1,3-bis-(diphenylphosphino)propane; palladium diacetate T=120°C;

copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; triethylamine in N,N-dimethyl-formamide Heating;

1: aq. NaClO2, H2O2 / acetonitrile 2: (COCl)2 4: 21 percent / Pd(PPh3)2Cl2, NaOPiv / N,N-dimethyl-acetamide / 10 h / 80 °C / Heating View Scheme

1: trifuoro-methanesulfonic acid 2-formyl-phenyl ester; immobilized on REM resin N-CBz-α-phosphonylglycine With 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Horner-Emmons reaction; 12 h; 2: With [(t-Bu)3PH]BF4; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in ethylene glycol dimethyl ether T=100°C; 38 h; 3: methanol With sodium methylate in tetrahydrofuran T=20°C; 12 h; Further stages.;

Multistep reaction;

palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene T=120°C; 24 h; Sealed tubeInert atmosphere;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium acetate in tetrahydrofuran Suzuki-Miyaura cross-coupling; RefluxInert atmosphere;