4-(4-溴苯基)-4-氰基哌啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: 2-(4-bromophenyl)ethanenitrile With sodium hydride in dimethyl sulfoxide
T=0°C; 1 h;
2: N-(2,2'-bischloro)diethyl-N-(1,1-dimethylethoxy)carbonyl amine in dimethyl sulfoxide
T=0 - 20°C; 3 h;
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP1956009 A1, 2008 ;
Location in patent: Page/Page column 99 ;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2006/136830 A1, 2006 ;
Location in patent: Page/Page column 182-183 ;
WO 2006/136830 A1
反应条件
hydrogenchloride; water
72 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2006/136830 A1, 2006 ;
Location in patent: Page/Page column 183 ;
WO 2006/136830 A1
