2-羟基-1-吡咯烷羧酸叔丁酯合成路线 （共 17 条）
反应条件
4 A molecular sieve; boron trifluoride diethyl etherate in diethyl ether
参考文献
Rassu, Gloria; Pinna, Luigi; Spanu, Pietro; Ulgheri, Fausta; Casiraghi, Giovanni
Tetrahedron Letters, 1994 , vol. 35, # 23 p. 4019 - 4022
反应条件
toluene-4-sulfonic acid Yield given;
参考文献
Pichon, Marianne; Figadere, Bruno; Cave, Andre
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7963 - 7966
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 1 h; Inert atmosphere; 2: 2-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester in N,N-dimethyl-formamide; mineral oil T=20°C; Horner-Wadsworth-Emmons reaction; 12 h; Inert atmosphere;
参考文献
Niphakis, Micah J.; Georg, Gunda I.
Organic Letters, 2011 , vol. 13, # 2 p. 196 - 199
反应条件
diisobutylaluminium hydride
T=-78°C;
参考文献
Yoshitomi, Yayoi; Arai, Hiromi; Makino, Kazuishi; Hamada, Yasumasa
Tetrahedron, 2008 , vol. 64, # 51 p. 11568 - 11579
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane
T=-78 - 20°C;
参考文献
Kokotos, Christoforos G.; Aggarwal, Varinder K.
Chemical Communications, 2006 , # 20 p. 2156 - 2158
反应条件
hydrogen; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; [rhodium(I)(carbonyl)2(acetylacetonate)] in tetrahydrofuran
T=70°C; P=15001.2 Torr; 20 h;
参考文献
Schmidt, Axel M.; Eilbracht, Peter
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 12 p. 2333 - 2343
反应条件
in tetrahydrofuran; hydrogenchloride; hexanes - ether; chloroform
参考文献
Merck and Co., Inc.
Patent: US4634715 A1, 1987 ;
US 4634715 A
反应条件
lead(IV) acetate in benzene
T=20°C; modified Hunsdiecker reaction; 20 h;
参考文献
Kaname; Mashige; Yoshifuji
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 5 p. 531 - 536
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 - 0 °C
1.2: 67 percent / tetrahydrofuran / -78 - 20 °C
2.1: 87 percent / DIBAL-H / tetrahydrofuran / 2 h / -78 °C
View Scheme
参考文献
Gawley, Robert E.; Barolli, Graciela; Madan, Sachin; Saverin, Michele; O'Connor, Sean
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1759 - 1761
反应条件
dicarbonylacetylacetonato rhodium (I); hydrogen; (R,S)-Binaphos in toluene
T=60°C; P=15001.5 Torr; 20 h; optical yield given as percent eeenantioselective reaction;
参考文献
Zhang, Xiaowei; Cao, Bonan; Yu, Shichao; Zhang, Xumu
Angewandte Chemie - International Edition, 2010 , vol. 49, # 24 p. 4047 - 4050
