[2-(4-溴-吡唑-1-基)-乙基]-二甲胺合成路线 （共 3 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 12 h;
参考文献
ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu
Patent: WO2013/53983 A1, 2013 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 4-bromo(1H)-pyrazole; 1-bromo-2-chloro-ethane With caesium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h; Microwave irradiation;
2: dimethyl amine in tetrahydrofuran; N,N-dimethyl-formamide
T=60 - 100°C; Microwave irradiation;
参考文献
GLAXOSMITHKLINE LLC; DEMONT, Emmanuel, Hubert; GARTON, Neil, Stuart; GOSMINI, Romain, Luc, Marie; HAYHOW, Thomas, George, Christopher; SEAL, Jonathan; WILSON, David, Matthew; WOODROW, Michael, David
Patent: WO2011/54841 A1, 2011 ;
Location in patent: Page/Page column 46 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane
T=100°C; 12 h; Inert atmosphereSealed tube;
参考文献
ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu
Patent: WO2013/53983 A1, 2013 ;
Location in patent: Page/Page column 29 ;
