in dichloromethane T=0 - 5°C; 1 h;

1: in dichloromethane T=20 - 30°C; 14 - 16 h; Heating / reflux; 2: With sodium hydrogencarbonate in water; acetone T=0 - 20°C; 0.5 - 1.5 h; Product distribution / selectivity;

in tetrahydrofuran; toluene 2.5 h; Heating;

triethylamine in dichloromethane T=20°C;

1: 2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid; (S,S,S)-2-azabicyclolt;3.3.0gt;octane-3-carboxylic acid hydrochloride With sodium hydroxide; hydrogenation catalyst in water T=20 - 25°C; pH=10 - 11; 2: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride in water T=20 - 25°C; pH=10 - 11; 3 - 4 h; 3: With hydrogenchloride in water T=15 - 20°C; pH=4.4 - 5.2; 2.5 - 2.75 h; Product distribution / selectivity;

1: in water; ethyl acetate T=19 - 20°C; pH=10 - 11; 5 h; 2: T=30°C; pH=4.3 - 4.7; 0.166667 h;

1: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 1 h; 2: sodium (indan-2-yl)glycinate in tetrahydrofuran T=20°C; 3 h; 3: With hydrogenchloride in water pH=2 - 3; Product distribution / selectivity;

1: (2S,3aR,7aS)-octahydroindolecarboxylic acid With triethylamine in dichloromethane T=20°C; 0.5 h; 2: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride in dichloromethane T=20°C; 3 h; 3: With hydrogenchloride in dichloromethane; water T=15°C; pH=4.2; Product distribution / selectivity;

1: in dichloromethane T=0 - 5°C; 2 h; 2: With acetic acid in water Product distribution / selectivity;

triethylamine in water; acetone T=0 - 25°C; pH=9.0 - 10.6; 2 h; Product distribution / selectivity;