反应条件
1: 4-bromo-but-2-enoyl chloride; 4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)-6-amino-7-ethoxyquinoline-3-carbonitrile With N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=0°C; 2 h;
2: dimethyl amine With sodium iodide in N,N-dimethyl-formamide
T=20°C;
参考文献
Tsou, Hwei-Ru; Overbeek-Klumpers, Elsebe G.; Hallett, William A.; Reich, Marvin F.; Floyd, M. Brawner; Johnson, Bernard D.; Michalak, Ronald S.; Nilakantan, Ramaswamy; Discafani, Carolyn; Golas, Jonathan; Rabindran, Sridhar K.; Shen, Ru; Shi, Xiaoqing; Wang, Yu-Fen; Upeslacis, Janis; Wissner, Allan
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 1107 - 1131