6-氨基-4-(3-氯-4-(吡啶-2-取代甲氧基)苯胺)-7-乙氧基喹啉-3-甲腈合成路线 （共 17 条）
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 60 °C
2: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
3: toluene / 90 °C
4: dowtherm A / 250 °C
5: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
6: pyridine hydrochloride / isopropyl alcohol / Reflux
7: hydrogenchloride / water / 5 h / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
2: toluene / 90 °C
3: dowtherm A / 250 °C
4: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
5: pyridine hydrochloride / isopropyl alcohol / Reflux
6: hydrogenchloride / water / 5 h / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: acetic acid / 60 °C
2: potassium carbonate / N,N-dimethyl-formamide / 60 °C
3: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
4: toluene / 90 °C
5: dowtherm A / 250 °C
6: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
7: pyridine hydrochloride / isopropyl alcohol / Reflux
8: hydrogenchloride / water / 5 h / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: toluene / 90 °C
2: dowtherm A / 250 °C
3: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
4: pyridine hydrochloride / isopropyl alcohol / Reflux
5: hydrogenchloride / water / 5 h / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: dowtherm A / 250 °C
2: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
3: pyridine hydrochloride / isopropyl alcohol / Reflux
4: hydrogenchloride / water / 5 h / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 50 - 60 °C
2: iron; ammonium chloride / ethanol; water / 1 h / |Reflux
3: methanesulfonic acid / ethanol / 2 h / |Reflux
4: hydrogenchloride; water / |Reflux
View Scheme
参考文献
Gu, Ning; Yang, Jiabin; Wang, Peng; Li, Lushen; Chen, Yang; Ji, Min
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3105 - 3110
反应条件
1: iron; ammonium chloride / ethanol; water / 1 h / |Reflux
2: methanesulfonic acid / ethanol / 2 h / |Reflux
3: hydrogenchloride; water / |Reflux
View Scheme
参考文献
Gu, Ning; Yang, Jiabin; Wang, Peng; Li, Lushen; Chen, Yang; Ji, Min
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3105 - 3110
