1: lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 5 °C 2: hydrogen / Pd/C / methanol View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=20&deg;C;&nbsp;0.25&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 98 percent / triethylamine / methanol / 3 h<br />2: 90 percent / toluenesulfonic acid / toluene / 3 h / Heating<br />3: thionyl chloride / CH₂Cl₂ / 0.5 h / Heating<br />4: pyridine / CH₂Cl₂ / 0.25 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 90 percent / toluenesulfonic acid / toluene / 3 h / Heating<br />2: thionyl chloride / CH₂Cl₂ / 0.5 h / Heating<br />3: pyridine / CH₂Cl₂ / 0.25 h / 20 &deg;C<br /> <br /> &nbsp;