(3-氨基-2,6-二氟苯基)甲醇合成路线 （共 5 条）
反应条件
hydrogen; Pd/C in ethyl acetate
Reduction; 4 h;
参考文献
Yoshida, Yoshiki; Barrett, David; Azami, Hidenori; Morinaga, Chizu; Matsumoto, Satoru; Matsumoto, Yoshimi; Takasugi, Hisashi
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2647 - 2666
反应条件
1: 42 percent / thionyl chloride / 1.) -15 to -5 deg C, 0.5 h, 2.) room temp., overnight
2: 88 percent / SnCl2*2H2O, conc. HCl / methanol / 20 h / Ambient temperature
3: LiAlH4 / tetrahydrofuran / 1.) -15 to -5 deg C, 50 min, 2.) 0-5 deg C, 30 min
View Scheme
参考文献
Tani; Mushika; Yamaguchi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3530 - 3543
反应条件
1: 95 percent / fuming HNO3, conc. H2SO4 / 1 h / 20 - 25 °C
2: 42 percent / thionyl chloride / 1.) -15 to -5 deg C, 0.5 h, 2.) room temp., overnight
3: 88 percent / SnCl2*2H2O, conc. HCl / methanol / 20 h / Ambient temperature
4: LiAlH4 / tetrahydrofuran / 1.) -15 to -5 deg C, 50 min, 2.) 0-5 deg C, 30 min
View Scheme
参考文献
Tani; Mushika; Yamaguchi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3530 - 3543
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
1.) -15 to -5 deg C, 50 min, 2.) 0-5 deg C, 30 min; Yield given;
参考文献
Tani; Mushika; Yamaguchi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3530 - 3543
反应条件
1: 88 percent / SnCl2*2H2O, conc. HCl / methanol / 20 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 1.) -15 to -5 deg C, 50 min, 2.) 0-5 deg C, 30 min
View Scheme
参考文献
Tani; Mushika; Yamaguchi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3530 - 3543
