5-(苄氧基羰基)-1H-吡咯-2-羧酸合成路线 （共 4 条）
反应条件
potassium permanganate in water; acetone
T=20 - 40°C; 2 h;
参考文献
Schmuck, Carsten; Bickert, Volker; Merschky, Michael; Geiger, Lars; Rupprecht, Daniel; Dudaczek, Juergen; Wich, Peter; Rehm, Thomas; Machon, Uwe
European Journal of Organic Chemistry, 2008 , # 2 p. 324 - 329
反应条件
1.1: KOH / dimethylsulfoxide
1.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C
2.1: POCl3 / 1,2-dichloro-ethane / 0.35 h / 0 - 20 °C
2.2: 1,2-dichloro-ethane / 0.33 h / Heating
2.3: 62 percent / aq. NaOAc / 1,2-dichloro-ethane / 0.25 h / Heating
3.1: 61 percent / aq. KH2PO4; KMnO4 / 2-methyl-propan-2-ol / 0.58 h / 20 °C
View Scheme
参考文献
Nativi, Cristina; Cacciarini, Martina; Francesconi, Oscar; Vacca, Alberto; Moneti, Gloriano; Ienco, Andrea; Roelens, Stefano
Journal of the American Chemical Society, 2007 , vol. 129, # 14 p. 4377 - 4385
反应条件
1.1: POCl3 / 1,2-dichloro-ethane / 0.35 h / 0 - 20 °C
1.2: 1,2-dichloro-ethane / 0.33 h / Heating
1.3: 62 percent / aq. NaOAc / 1,2-dichloro-ethane / 0.25 h / Heating
2.1: 61 percent / aq. KH2PO4; KMnO4 / 2-methyl-propan-2-ol / 0.58 h / 20 °C
View Scheme
参考文献
Nativi, Cristina; Cacciarini, Martina; Francesconi, Oscar; Vacca, Alberto; Moneti, Gloriano; Ienco, Andrea; Roelens, Stefano
Journal of the American Chemical Society, 2007 , vol. 129, # 14 p. 4377 - 4385
反应条件
1.1: KOH / dimethylsulfoxide
1.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C
2.1: POCl3 / 1,2-dichloro-ethane / 0.35 h / 0 - 20 °C
2.2: 1,2-dichloro-ethane / 0.33 h / Heating
2.3: 62 percent / aq. NaOAc / 1,2-dichloro-ethane / 0.25 h / Heating
3.1: 61 percent / aq. KH2PO4; KMnO4 / 2-methyl-propan-2-ol / 0.58 h / 20 °C
View Scheme
参考文献
Nativi, Cristina; Cacciarini, Martina; Francesconi, Oscar; Vacca, Alberto; Moneti, Gloriano; Ienco, Andrea; Roelens, Stefano
Journal of the American Chemical Society, 2007 , vol. 129, # 14 p. 4377 - 4385
