2-硼-6-[[(1,1-二甲基乙基)二甲基甲硅烷基]氧基]-1H-吲哚-1-羧酸-1-(1,1-二甲基乙基)酯合成路线 （共 4 条）
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; water
T=-78°C; 0.583333 h;
2: With boric acid trimethyl ester in tetrahydrofuran
T=0°C; 2 h;
3: With potassium hydrogensulfate; sulfuric acid; ammonium chloride
more than 3 stages;
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1598348 A1, 2005 ;
Location in patent: Page/Page column 34 ;
EP 1598348 A1
反应条件
1: 6-(tert-butyldimethylsilanyloxy)indole-1-carboxylic acid tert-butyl ester With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 1.16667 h;
2: boric acid trimethyl ester in tetrahydrofuran; pentane
T=0°C; 2 h;
参考文献
Aventis Pharma S.A.
Patent: US2005/137171 A1, 2005 ;
Location in patent: Page/Page column 37 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
2: tri-isopropoxy-borane; lithium diisopropyl amide / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Herdemann, Matthias; Weber, Alexander; Jonveaux, Jerome; Schwoebel, Frank; Stoeck, Michael; Heit, Isabelle
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1852 - 1856
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
2: tri-isopropoxy-borane; lithium diisopropyl amide / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Herdemann, Matthias; Weber, Alexander; Jonveaux, Jerome; Schwoebel, Frank; Stoeck, Michael; Heit, Isabelle
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1852 - 1856
