1-溴-2-甲氧基-4-(三氟甲氧基)苯合成路线 (共 2 条)
反应条件
1: 2-Methoxy-4-trifluoromethoxy bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-77 - -62°C; 0.166667 h; 2: boric acid trimethyl ester in tetrahydrofuran; hexane T=-76.3 - -63.2°C; 1.16667 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water pH=1;
参考文献
NEUROGEN CORPORATION; AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/23806 A2, 2005 ;
Location in patent: Page/Page column 57-58 ;
WO 2005/023806 A2
反应条件
1: 2-bromo-5-(trifluoromethyloxy)phenol With sodium hydroxide in water; toluene
T=1 - 10°C; 0.333333 h;
2: dimethyl sulfate With tetrabutylammomium bromide in water; toluene
T=12 - 15°C;
参考文献
NEUROGEN CORPORATION; AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/23806 A2, 2005 ;
Location in patent: Page/Page column 57-58 ;
WO 2005/023806 A2