3,5-二溴-6-乙基吡啶-2-胺合成路线 （共 2 条）
反应条件
N-bromosuccinmide in dichloromethane
T=20°C; 0.166667 h;
参考文献
NEUROGEN CORPORATION; AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/23806 A2, 2005 ;
Location in patent: Page/Page column 61 ;
WO 2005/023806 A2
反应条件
1: [1,3-bis(diphenylphosphino) propane] dichloronickel(II) / toluene; 1,4-dioxane / 16 h / Inert atmosphere; Reflux
2: N-bromosuccinmide / N,N-dimethyl-formamide / 2.25 h / 10 - 20 °C
View Scheme
参考文献
GILEAD SCIENCES, INC.; BLOMGREN, Peter; CURRIE, Kevin, S; KROPF, Jeffrey, E.; LEE, Seung, H.; MITCHELL, Scott, A.; SCHMITT, Aaron, C.; XU, Jianjun; ZHAO, Zhongdong
Patent: WO2011/112995 A1, 2011 ;
WO 2011/112995 A1
