4-(3-氯-2-氟苯胺)-6,7-二羟基喹唑啉合成路线 （共 5 条）
反应条件
pyridine hydrochloride
T=170°C; 2.16667 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/26150 A1, 2005 ;
Location in patent: Page/Page column 115; 116 ;
WO 2005/026150 A1
反应条件
pyridine hydrochloride
T=150°C; 3 h;
参考文献
Harris, Craig S.; Hennequin, Laurent F.; Kettle, Jason G.; Willerval, Olivier A.
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7715 - 7719
反应条件
1: 98 percent / propan-2-ol / Heating
2: 67 percent / pyridine hydrochloride / 3 h / 150 °C
View Scheme
参考文献
Harris, Craig S.; Hennequin, Laurent F.; Kettle, Jason G.; Willerval, Olivier A.
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7715 - 7719
反应条件
1.1: 45 percent / methionine; MeSO3H / 3 h / 100 °C
2.1: pyridine / 100 °C
2.2: 70 percent / SOCl2 / 16 h / Heating
3.1: 98 percent / propan-2-ol / Heating
4.1: 67 percent / pyridine hydrochloride / 3 h / 150 °C
View Scheme
参考文献
Harris, Craig S.; Hennequin, Laurent F.; Kettle, Jason G.; Willerval, Olivier A.
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7715 - 7719
反应条件
1.1: pyridine / 100 °C
1.2: 70 percent / SOCl2 / 16 h / Heating
2.1: 98 percent / propan-2-ol / Heating
3.1: 67 percent / pyridine hydrochloride / 3 h / 150 °C
View Scheme
参考文献
Harris, Craig S.; Hennequin, Laurent F.; Kettle, Jason G.; Willerval, Olivier A.
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7715 - 7719
