2,6-二氯-N-甲基-N-(甲基氧基)-4-吡啶羧酰胺合成路线 （共 2 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane
T=20°C; 20 h;
参考文献
Hay, Michael P.; Turcotte, Sandra; Flanagan, Jack U.; Bonnet, Muriel; Chan, Denise A.; Sutphin, Patrick D.; Nguyen, Phuong; Giaccia, Amato J.; Denny, William A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 787 - 797
反应条件
1: 2,6-dichloropyridine-4-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 2 h;
2: N,O-dimethyl-hydroxylamine With triethylamine
T=0 - 20°C; 2 h; Neat (no solvent);
参考文献
Eberle, Martin; Stierli, Daniel; Pillonel, Christian; Ziegler, Hugo
Patent: US2003/236256 A1, 2003 ;
Location in patent: Page 39 ;
