4-(1-羟基乙基)苯甲酸甲酯合成路线 （共 18 条）
反应条件
1: chromium (III)-oxide; calcium carbonate; air / 150 °C 2: copper oxide-chromium oxide; methanol / 150 °C / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 674
反应条件
1: unter Einleiten von Chlorwasserstoff 2: chromium (III)-oxide; calcium carbonate; air / 150 °C 3: copper oxide-chromium oxide; methanol / 150 °C / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 674
反应条件
triethylsilane; lt;5,10,15,20-tetrakis(2,6-dichlorophenyl)porphinatogt;cobalt(II); oxygen; phosphorous acid trimethyl ester 1.) 2-propanol, dichloromethane, 28 deg C, 1 atm, 30 min, 2.) 2-propanol, dichloromethane, RT, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemistry Letters, , # 6 p. 925 - 928
反应条件
C50H42ClN2O3Ru in chloroform T=25°C; Molecular sieveResolution of racemate; Kinetics; enantioselective reaction;
参考文献
Mizoguchi, Hirotaka; Uchida, Tatsuya; Katsuki, Tsutomu
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3178 - 3182
Angew. Chem., 2014 , vol. 126, # 12 p. 3242 - 3246,5
反应条件
vinyl acetate; Lipase PS in tetrahydrofuran T=30°C; 16 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/5646 A2, 2009 ;
Location in patent: Page/Page column 160 ;
WO 2009/005646 A2
反应条件
C50H42ClN2O3Ru in chloroform T=25°C; Molecular sieveResolution of racemate; Kinetics; enantioselective reaction;
参考文献
Mizoguchi, Hirotaka; Uchida, Tatsuya; Katsuki, Tsutomu
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3178 - 3182
Angew. Chem., 2014 , vol. 126, # 12 p. 3242 - 3246,5
反应条件
zinc(II) iodide in 1,2-dichloro-ethane
0.75 h; Heating;
参考文献
Guindon, Yvan; Frenette, Richard; Fortin, Rejean; Rokach, Joshua
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1357 - 1359
反应条件
1: With potassium hydroxide in tetrahydrofuran; methanol; water
T=20°C;
2: With hydrogenchloride in methanol; water
参考文献
MERCK and CO., INC.
Patent: WO2008/10985 A2, 2008 ;
Location in patent: Page/Page column 155 ;
WO 2008/010985 A2
