1: 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 7.3 h; 2: With sodium sulfate T=0 - 20°C; 16 h; 3: di-tert-butyl dicarbonate With sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 16 h;

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / |Reflux 2: dichloromethane / 0 - 20 °C View Scheme

1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 5 h; Heating / reflux; 2: With water; sodium sulfate in tetrahydrofuran T=0 - 20°C; 16 h;

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / |Reflux 2: dichloromethane / 0 - 20 °C 3: hydrogen; palladium(II) oxide hydrate / methanol View Scheme

1: With trifluoroacetic acid in dichloromethane T=0 - 20°C; 16.75 h; 2: With sodium hydrogencarbonate in dichloromethane; water

hydrogen; palladium 10 on activated carbon in ethanol T=25°C; 12 h;

trifluoroacetic acid in dichloromethane T=0 - 20°C; 19 h;

1: With sodium hydroxide; water 0.5 h; 2: With hydrogenchloride in water; ethyl acetate pH=4;