N-[4-[(3-氯-4-氟苯基)氨基]-3-氰基-7-乙氧基-6-喹啉基]乙酰胺合成路线 （共 8 条）
反应条件
hydrogenchloride in water Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
2: pyridine hydrochloride / isopropyl alcohol / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 60 °C
2: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
3: toluene / 90 °C
4: dowtherm A / 250 °C
5: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
6: pyridine hydrochloride / isopropyl alcohol / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
2: toluene / 90 °C
3: dowtherm A / 250 °C
4: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
5: pyridine hydrochloride / isopropyl alcohol / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: acetic acid / 60 °C
2: potassium carbonate / N,N-dimethyl-formamide / 60 °C
3: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
4: toluene / 90 °C
5: dowtherm A / 250 °C
6: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
7: pyridine hydrochloride / isopropyl alcohol / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: toluene / 90 °C
2: dowtherm A / 250 °C
3: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
4: pyridine hydrochloride / isopropyl alcohol / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: dowtherm A / 250 °C
2: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
3: pyridine hydrochloride / isopropyl alcohol / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
pyridine hydrochloride in isopropyl alcohol
Reflux;
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
