(5-甲基-1,3-噻唑-4-基)甲醇合成路线 （共 3 条）
反应条件
methanol; lithium borohydride in tetrahydrofuran
T=20°C; 16 h; Inert atmosphereCooling with ice;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00348 ;
反应条件
1: With acetic anhydride
T=110°C; 16 h;
2: With hydrogenchloride in methanol
参考文献
Russell, Michael G. N.; Carling, Robert W.; Atack, John R.; Bromidge, Frances A.; Cook, Susan M.; Hunt, Peter; Isted, Catherine; Lucas, Matt; McKernan, Ruth M.; Mitchinson, Andrew; Moore, Kevin W.; Narquizian, Robert; Macaulay, Alison J.; Thomas, David; Thompson, Sally-Anne; Wafford, Keith A.; Castro, Jose L.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1367 - 1383
反应条件
1.1: 21 percent / m-CPBA / CH2Cl2 / 16 h / 20 °C
2.1: Ac2O / 16 h / 110 °C
2.2: HCl(g) / methanol
View Scheme
参考文献
Russell, Michael G. N.; Carling, Robert W.; Atack, John R.; Bromidge, Frances A.; Cook, Susan M.; Hunt, Peter; Isted, Catherine; Lucas, Matt; McKernan, Ruth M.; Mitchinson, Andrew; Moore, Kevin W.; Narquizian, Robert; Macaulay, Alison J.; Thomas, David; Thompson, Sally-Anne; Wafford, Keith A.; Castro, Jose L.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1367 - 1383
