(2S)-2-[二苯基[(三甲基硅酯)氧基]甲基]-吡咯烷合成路线 （共 10 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Marigo, Mauro; Wabnitz, Tobias C.; Fielenbach, Doris; Jorgensen, Karl Anker
Angewandte Chemie - International Edition, 2005 , vol. 44, # 5 p. 794 - 797
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C; 17 h;
参考文献
Hayashi, Yujiro; Gotoh, Hiroaki; Hayashi, Takaaki; Shoji, Mitsuru
Angewandte Chemie - International Edition, 2005 , vol. 44, # 27 p. 4212 - 4215
参考文献
WO2007/112358 A1, ;
Page/Page column 39 ;
反应条件
in dichloromethane T=0 - 20°C;
参考文献
Chemistry - A European Journal, , vol. 11, # 3 p. 939 - 944
反应条件
1.1: tetrahydrofuran / 20 °C / Inert atmosphere 1.2: 16 h / Reflux; Inert atmosphere 2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Molecules, , vol. 17, # 5 p. 5626 - 5650
反应条件
1.1: potassium carbonate / 7.5 h / 0 - 20 °C / Inert atmosphere 2.1: tetrahydrofuran / 20 °C / Inert atmosphere 2.2: 16 h / Reflux; Inert atmosphere 3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Molecules, , vol. 17, # 5 p. 5626 - 5650
反应条件
1: (S)-1-ethyl 2-methyl pyrrolidine-1,2-dicarboxylate; phenyl-magnesium bromide; 4-methoxyphenyl magnesium bromide in tetrahydrofuran T=0°C; Grignard reaction; 3.5 h; Inert atmosphere; 2: With potassium hydroxide in methanol 24 h; Reflux; 3: trimethylsilyl trifluoromethanesulfonate; t-butyldimethylsiyl triflate With 2,6-dimethylpyridine in dichloromethane T=0 - 20°C; 12 h;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 95 - 99
参考文献
Journal of the American Chemical Society, , vol. 134, # 15 p. 6741 - 6750
反应条件
in benzene-d6 T=20°C; Molecular sieve;
参考文献
Patora-Komisarska, Krystyna; Benohoud, Meryem; Ishikawa, Hayato; Seebach, Dieter; Hayashi, Yujiro
Helvetica Chimica Acta, 2011 , vol. 94, # 5 p. 719 - 745
反应条件
1: dimethylsulfoxide-d6
2: dimethylsulfoxide-d6
View Scheme
参考文献
Carneros, Hector; Sanchez, Dani; Vilarrasa, Jaume
Organic Letters, 2014 , vol. 16, # 11 p. 2900 - 2903
