N-丙基-(2s)-(9ci)-2-吡咯烷羧酰胺合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 2 h;
参考文献
Rodriguez-Llansola, Francisco; Miravet, Juan F.; Escuder, Beatriu
Chemistry - A European Journal, 2010 , vol. 16, # 28 p. 8480 - 8486
反应条件
1: HATU; diethylamine / dimethylformamide / 16 h / 25 °C
2: HCl / dioxane
View Scheme
参考文献
Jain; Sundram; Lopez; Neckermann; Wu; Hackbarth; Chen; Wang; Ryder; Weidmann; Patel; Trias; White; Yuan
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4223 - 4228
反应条件
1: aq. NaHCO3 / dioxane / 16 h
2: HATU; diethylamine / dimethylformamide / 16 h / 25 °C
3: HCl / dioxane
View Scheme
参考文献
Jain; Sundram; Lopez; Neckermann; Wu; Hackbarth; Chen; Wang; Ryder; Weidmann; Patel; Trias; White; Yuan
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4223 - 4228
反应条件
hydrogen bromide in acetic acid
参考文献
Kasafirek, Evzen; Fric, Premysl; Slaby, Jan; Kocna, Petr
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 12 p. 3034 - 3041
反应条件
1: ethyl chloroformate, N-ethylpiperidine
2: 36percent HBr / acetic acid
View Scheme
参考文献
Kasafirek, Evzen; Fric, Premysl; Slaby, Jan; Kocna, Petr
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 12 p. 3034 - 3041
参考文献
Nilsson, Mikael; Haemaelaeinen, Markku; Ivarsson, Maria; Gottfries, Johan; Xue, Yafeng; Hansson, Sebastian; Isaksson, Roland; Fex, Tomas
Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2708 - 2715
