N-[(1-甲基环丙基)磺酰基]氨基甲酸1,1-二甲基乙酯合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH and CO KG
Patent: WO2007/9227 A1, 2007 ;
Location in patent: Page/Page column 43 ;
WO 2007/009227 A1
反应条件
1: N-tert-butyloxycarbonylcyclopropanesulfonamide With n-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran
T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH and CO KG
Patent: WO2007/9227 A1, 2007 ;
Location in patent: Page/Page column 43 ;
WO 2007/009227 A1
反应条件
1: N-tert-butyloxycarbonylcyclopropanesulfonamide With n-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH and CO KG
Patent: WO2006/7700 A1, 2006 ;
Location in patent: Page/Page column 80-81 ;
