2-溴-3-氧代丁酸乙酯合成路线 （共 43 条）
反应条件
1: acetic acid; hydrogen bromide / 100 °C 2: ethanol / 1 h / 20 °C 3: potassium carbonate / dichloromethane / 18 h / 20 °C / |Cooling with ice View Scheme
参考文献
Makena, Anne; Van Berkel, Sander S.; Lejeune, Clarisse; Owens, Raymond J.; Verma, Anil; Salimraj, Ramya; Spencer, James; Brem, Juergen; Schofield, Christopher J.
ChemMedChem, 2013 , vol. 8, # 12 p. 1923 - 1929
反应条件
ethanol T=20°C; 0.333333 h; Green chemistry; regioselective reaction;
参考文献
Luo, Laichun; Meng, Lanlan; Sun, Qi; Ge, Zemei; Li, Runtao
Tetrahedron Letters, 2014 , vol. 55, # 1 p. 259 - 263
反应条件
zur Umlagerung ist ausser der Anwesenheit von HBr auch Belichtung oder Gegenwart von Luftsauerstoff oder Peroxyd erforderlich;
参考文献
Makena, Anne; Van Berkel, Sander S.; Lejeune, Clarisse; Owens, Raymond J.; Verma, Anil; Salimraj, Ramya; Spencer, James; Brem, Juergen; Schofield, Christopher J.
ChemMedChem, 2013 , vol. 8, # 12 p. 1923 - 1929
反应条件
in ethanol Heating / reflux;
参考文献
US2003/236227 A1, ;
Page 3; sheet 33 ;
US 20030236227 A1
反应条件
in benzene Cycloaddition; 8 h; Heating;
参考文献
Synthetic Communications, , vol. 29, # 18 p. 3227 - 3236
反应条件
T=55°C; 0.166667 h; neat (no solvent);
参考文献
Chunavala, Kaushik C.; Joshi, Girdhar; Suresh, Eringathodi; Adimurthy, Subbarayappa
Synthesis, 2011 , # 4 art. no. Z27510SS, p. 635 - 641
反应条件
hydrogenchloride; dihydrogen peroxide; potassium bromide in toluene
T=20°C; 1.5 h;
参考文献
Okonya, John F.; Hoffman, Robert V.; Johnson, M. Catherine
Journal of Organic Chemistry, 2002 , vol. 67, # 4 p. 1102 - 1108
反应条件
Oxonereg;; NH4Br in methanol
T=20°C; 3 h; regioselective reaction;
参考文献
MacHarla, Arun Kumar; Chozhiyath Nappunni, Rohitha; Marri, Mahender Reddy; Peraka, Swamy; Nama, Narender
Tetrahedron Letters, 2012 , vol. 53, # 2 p. 191 - 195
反应条件
water; [C5mim][BF4]
T=125°C; P=2585.74 Torr; 0.0333333 h; microwave irradiation;
参考文献
Ranu, Brindaban C.; Chattopadhyay, Kalicharan; Jana, Ranjan
Tetrahedron, 2007 , vol. 63, # 1 p. 155 - 159
反应条件
N-bromosuccinmide; molybdenum dichloride dioxide in dichloromethane
T=30°C; 12 h;
参考文献
Jeyakumar, Kandasamy; Chand, Dillip Kumar
Synthesis, 2009 , # 2 p. 306 - 310
