N-(4-(6,7-二甲氧基喹啉-4-基氧基)苯基)-N-(4-氟苯基)环丙烷-1,1-二羧酰胺合成路线 （共 11 条）
反应条件
2,6-dimethylpyridine T=165°C; 18 h;
参考文献
WO2005/30140 A2, ;
Page/Page column 212 ;
WO 2005/030140 A2
反应条件
potassium carbonate in tetrahydrofuran; water T=15 - 30°C;
参考文献
WO2010/83414 A1, ;
Page/Page column 26 ;
反应条件
1: thionyl chloride; triethylamine / n-heptane; water; tetrahydrofuran 2: N,N-dimethyl-formamide; tetrahydrofuran 3: potassium carbonate / water; tetrahydrofuran View Scheme
参考文献
US2012/70368 A1, ;
US 20120070368 A1
US2012/252840 A1, ;
US 20120252840 A1
反应条件
1: thionyl chloride; triethylamine / n-heptane; water; tetrahydrofuran 2: N,N-dimethyl-formamide; tetrahydrofuran 3: potassium carbonate / water; tetrahydrofuran View Scheme
参考文献
US2012/70368 A1, ;
US 20120070368 A1
US2012/252840 A1, ;
US 20120252840 A1
反应条件
1: trichlorophosphate / acetonitrile / 13 h / 60 - 77 °C 2: sodium t-butanolate / isobutyramide / 13 h / 20 - 105 °C 3: potassium carbonate / water; tetrahydrofuran / 0.33 h / 30 °C View Scheme
反应条件
1: sodium t-butanolate / isobutyramide / 13 h / 20 - 105 °C 2: potassium carbonate / water; tetrahydrofuran / 0.33 h / 30 °C View Scheme
反应条件
1: N,N-dimethyl-formamide; tetrahydrofuran 2: potassium carbonate / water; tetrahydrofuran View Scheme
参考文献
US2012/252840 A1, ;
US 20120252840 A1
反应条件
1: potassium formiate; formic acid / palladium / water; tetrahydrofuran 2: potassium carbonate / water; tetrahydrofuran View Scheme
参考文献
US2012/70368 A1, ;
US 20120070368 A1
US2012/252840 A1, ;
US 20120252840 A1
反应条件
1: tetrahydrofuran / 10 h / 10 °C / |Large scale 2: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 12 - 17 °C / |Large scale 3: potassium carbonate / water; tetrahydrofuran / 0.33 h / 30 °C / |Large scale View Scheme
反应条件
1: dimethylammonium 2,4-dichlorophenoxyacetate / water; N,N-dimethyl acetamide 2: potassium carbonate / water; tetrahydrofuran View Scheme
参考文献
US2012/252840 A1, ;
US 20120252840 A1
