2: NH2OH*HCl / 0.67 h 3: 80 percent / Na / pentan-1-ol / 80 °C / Heating 4: 87 percent / triethylamine / CH2Cl2 / 12 h / 0 °C 5: HCl; H2 / Pd/C 10percent / ethanol / 12 h / 60 °C / 11015.3 Torr 6: triethylamine / acetone / Heating 7: 10percent H2SO4 / Heating 8: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT View Scheme

1: NH2OH*HCl / 0.67 h 2: 80 percent / Na / pentan-1-ol / 80 °C / Heating 3: 87 percent / triethylamine / CH2Cl2 / 12 h / 0 °C 4: HCl; H2 / Pd/C 10percent / ethanol / 12 h / 60 °C / 11015.3 Torr 5: triethylamine / acetone / Heating 6: 10percent H2SO4 / Heating 7: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT View Scheme

1: 87 percent / triethylamine / CH2Cl2 / 12 h / 0 °C 2: HCl; H2 / Pd/C 10percent / ethanol / 12 h / 60 °C / 11015.3 Torr 3: triethylamine / acetone / Heating 4: 10percent H2SO4 / Heating 5: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT View Scheme

1: HCl; H2 / Pd/C 10percent / ethanol / 12 h / 60 °C / 11015.3 Torr 2: triethylamine / acetone / Heating 3: 10percent H2SO4 / Heating 4: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT View Scheme

1: 80 percent / Na / pentan-1-ol / 80 °C / Heating 2: 87 percent / triethylamine / CH2Cl2 / 12 h / 0 °C 3: HCl; H2 / Pd/C 10percent / ethanol / 12 h / 60 °C / 11015.3 Torr 4: triethylamine / acetone / Heating 5: 10percent H2SO4 / Heating 6: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT View Scheme

1: triethylamine / acetone / Heating 2: 10percent H2SO4 / Heating 3: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT View Scheme

chloroformic acid ethyl ester; triethylamine 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT; Yield given. Multistep reaction;