3-N-boc-氨基-6-苯基吡啶合成路线 （共 3 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate
T=20°C; P=2585.81 Torr; 18 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/30213 A1, 2005 ;
Location in patent: Page/Page column 171 ;
WO 2005/030213 A1
反应条件
potassium carbonate; {PdCl2[(t-Bu)2PCl]2} in tetrahydrofuran; methanol
T=20 - 70°C; 1 h;
参考文献
Sun, Chongqing; Ewing, William R.; Sulsky, Richard B.; Huang, Yanting
Patent: US2006/155126 A1, 2006 ;
Location in patent: Page/Page column 11 ;
US 20060155126 A1
反应条件
1: With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether
T=-78°C; 0.25 h;
2: T=-10°C; 3 h;
3: With iodine in tetrahydrofuran; diethyl ether
T=-78°C; 2 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/30213 A1, 2005 ;
Location in patent: Page/Page column 171-172 ;
WO 2005/030213 A1
