4-氨基-3-氟-5-碘苯甲腈合成路线 （共 3 条）
反应条件
iodine cloride in dichloromethane
20 h;
参考文献
AMOREPACIFIC CORPORATION
Patent: WO2007/120012 A1, 2007 ;
Location in patent: Page/Page column 83; 129-130 ;
WO 2007/120012 A1
反应条件
sodium perborate; sodium tungstate; sulfuric acid; potassium iodide in water; acetic anhydride; acetic acid
T=50°C; 1.15 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/30213 A1, 2005 ;
Location in patent: Page/Page column 186-187 ;
WO 2005/030213 A1
反应条件
1: With borane-THF in tetrahydrofuran
T=0 - 20°C; Heating / reflux;
2: With hydrogenchloride; water in tetrahydrofuran
0.333333 h;
参考文献
AMOREPACIFIC CORPORATION
Patent: WO2007/120012 A1, 2007 ;
Location in patent: Page/Page column 83-84; 130 ;
WO 2007/120012 A1
