(9ci)-1-(二氟甲基)-1H-苯并咪唑合成路线 （共 9 条）
反应条件
potassium hydroxide in water; acetonitrile
T=-78 - 80°C; 4 h;
参考文献
Wang, Fei; Zhang, Laijun; Zheng, Ji; Hu, Jinbo
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 521 - 528
反应条件
potassium hydroxide in water; toluene
T=50°C; 4 h; Inert atmosphereSealed tube;
参考文献
Wang, Fei; Li, Lingchun; Ni, Chuanfa; Hu, Jinbo
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 344 - 351
反应条件
potassium hydroxide in acetonitrile
T=50°C;
参考文献
Zheng, Ji; Li, Ya; Zhang, Laijun; Hu, Jinbo; Meuzelaar, Gerrit Joost; Federsel, Hans-Juergen
Chemical Communications, 2007 , # 48 p. 5149 - 5151
反应条件
lithium iodide in triglyme (triethylene glycol dimethyl ether)
T=170°C; 1.5 h; Inert atmosphereMicrowave irradiation; Reagent/catalystSolventTemperatureTime;
参考文献
Surya Prakash; Krishnamoorthy, Sankarganesh; Ganesh, Somesh K.; Kulkarni, Aditya; Haiges, Ralf; Olah, George A.
Organic Letters, 2014 , vol. 16, # 1 p. 54 - 57
反应条件
1: 1H-benzo[d]imidazole With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in tetrahydrofuran
T=20°C; 0.0333333 h;
2: 1-chloro-1,1-difluoro-methane in tetrahydrofuran
T=20°C;
参考文献
Jonczyk, Andrzej; Nawrot, Ewelina; Kisielewski, Michal
Journal of Fluorine Chemistry, 2005 , vol. 126, # 11-12 p. 1587 - 1591
反应条件
1: 1H-benzo[d]imidazole With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h; Inert atmosphere;
2: PhSO(NTS)CF2D in N,N-dimethyl-formamide
T=20 - 60°C;
参考文献
Zhang, Wei; Wang, Fei; Hu, Jinbo
Organic Letters, 2009 , vol. 11, # 10 p. 2109 - 2112
反应条件
potassium hydroxide in dichloromethane; water
T=0°C; 0.5 h;
参考文献
Li, Lingchun; Wang, Fei; Ni, Chuanfa; Hu, Jinbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12390 - 12394
Angew. Chem., 2013 , vol. 125, # 47 p. 12616 - 12620,5
反应条件
in diethylene glycol dimethyl ether; water
T=160°C; 11 h;
参考文献
Poludnenko, V. G.; Didinskaya, O. B.; Pozharskii, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 4 p. 422 - 425
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 4 p. 520 - 523
反应条件
potassium hydroxide in water; acetone
T=40 - 50°C; 3 h; Product distribution;
参考文献
Poludnenko, V. G.; Didinskaya, O. B.; Pozharskii, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 4 p. 422 - 425
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 4 p. 520 - 523
