1-(二氟甲基)-2-甲基-(9ci)-1H-苯并咪唑合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=90°C;
参考文献
Levterov, Vadym; Grygorenko, Oleksandr O.; Mykhailiuk, Pavel K.; Tolmachev, Andrey A.
Synthesis, 2011 , # 8 art. no. N50310SS, p. 1243 - 1248
反应条件
water; zinc in methanol
T=20°C; 24 h;
参考文献
Bissky, German; Roeschenthaler, Gerd-Volker; Lork, Enno; Barten, Jan; Medebielle, Maurice; Staninets, Vasilij; Kolomeitsev, Alexander A.
Journal of Fluorine Chemistry, 2001 , vol. 109, # 2 p. 173 - 181
反应条件
in diethylene glycol dimethyl ether; water
T=160°C; 11 h;
参考文献
Poludnenko, V. G.; Didinskaya, O. B.; Pozharskii, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 4 p. 422 - 425
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 4 p. 520 - 523
反应条件
tetramethyl-ammonium fluoride in ethylene glycol dimethyl ether
5 h; Heating;
参考文献
Yagupolskii, Lev M.; Fedyuk, Dmitrij V.; Petko, Kirill I.; Troitskaya, Valeriya I.; Rudyk, Valentina I.; Rudyuk, Vitalij V.
Journal of Fluorine Chemistry, 2000 , vol. 106, # 2 p. 181 - 187
反应条件
1.1: NaH; Zn / acetonitrile / 3 h / -10 - -5 °C
1.2: 76 percent / acetonitrile / 16 h / -15 - 20 °C
2.1: 35 percent / Me4NF / 1,2-dimethoxy-ethane / 5 h / Heating
View Scheme
参考文献
Yagupolskii, Lev M.; Fedyuk, Dmitrij V.; Petko, Kirill I.; Troitskaya, Valeriya I.; Rudyk, Valentina I.; Rudyuk, Vitalij V.
Journal of Fluorine Chemistry, 2000 , vol. 106, # 2 p. 181 - 187
反应条件
in diethylene glycol dimethyl ether
T=150 - 160°C; 11 h; Product distribution;
参考文献
Poludnenko, V. G.; Didinskaya, O. B.; Pozharskii, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 4 p. 422 - 425
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 4 p. 520 - 523
