6-羟基-4,4,5,8-四甲基-3,4-二氢香豆素合成路线 （共 6 条）
反应条件
methanesulfonic acid
T=70°C; 3 h; Inert atmosphere;
参考文献
Ciampi, Simone; James, Michael; Le Saux, Guillaume; Gaus, Katharina; Justin Gooding
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 844 - 847
反应条件
methanesulfonic acid
T=90°C; 2 h;
参考文献
PROMEGA CORPORATION; BENINK, Helene; CALI, James, J.; DUELLMAN, Sarah; KLAUBERT, Dieter; LEIPPE, Donna; O'BRIEN, Martha; SHULTZ, John; VIDUGIRIENE, Jolanta; ZHOU, Wenhui; SOBOL, Mary
Patent: WO2013/33515 A1, 2013 ;
Location in patent: Paragraph 00171 ;
反应条件
sodium dithionite; methanesulfonic acid in diethyl ether; water
T=85°C; 3 h; Inert atmosphere;
参考文献
Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586
反应条件
sulfuric acid in benzene
8 h; Heating;
参考文献
King, Michael M.; Cohen, Louis A.
Journal of the American Chemical Society, 1983 , vol. 105, # 9 p. 2752 - 2760
反应条件
1: sodium dithionite / diethyl ether; water
2: methanesulfonic acid / 3 h / 70 °C / Inert atmosphere
View Scheme
参考文献
Ciampi, Simone; James, Michael; Le Saux, Guillaume; Gaus, Katharina; Justin Gooding
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 844 - 847
反应条件
1: Jone's reagent / diethyl ether / 38 h / 0 - 20 °C
2: sodium dithionite / diethyl ether; water
3: methanesulfonic acid / 3 h / 70 °C / Inert atmosphere
View Scheme
参考文献
Ciampi, Simone; James, Michael; Le Saux, Guillaume; Gaus, Katharina; Justin Gooding
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 844 - 847
