1-N-苄基-1-N-甲基-2-Boc-乙烷-1,2-二胺合成路线 （共 11 条）
反应条件
hydrogen; 20 palladium(II) hydroxide on carbon in methanol; water 2.5 h;
参考文献
US2011/262355 A1, ;
Page/Page column 136 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.5 h;
参考文献
Gassiot, Amaury Cazenave; Charton, Julie; Girault-Mizzi, Sophie; Gilleron, Pauline; Debreu-Fontaine, Marie-Ange; Sergheraert, Christian; Melnyk, Patricia
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4828 - 4832
反应条件
caesium carbonate; potassium iodide in acetone
T=20°C; 70 h;
参考文献
Beghyn, Terence B.; Charton, Julie; Leroux, Florence; Laconde, Guillaume; Bourin, Arnaud; Cos, Paul; Maes, Louis; Deprez, Benoit
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3222 - 3240
反应条件
triethylamine in chloroform
T=5 - 20°C; 16 h; Sealed tube;
参考文献
PHARMACOFORE, INC.; JENKINS, Thomas, E.; HUSFELD, Craig, O.; SEROOGY, Julie, D.; WRAY, Jonathan, W.
Patent: WO2011/133150 A1, 2011 ;
Location in patent: Page/Page column 300 ;
反应条件
1: With water; sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane
T=20°C; 16 h;
2: With sodium hydrogencarbonate in water; 1,2-dichloro-ethane
参考文献
Milne, Jill C.; Jirousek, Michael R.; Bemis, Jean E.; Smith, Jesse J.
Patent: US2010/41748 A1, 2010 ;
Location in patent: Page/Page column 120 ;
反应条件
triethanolamine in methanol; chloroform; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Jenkins, Thomas E.; Husfeld, Craig O.; Seroogy, Julie D.; Wray, Jonathan W.
Patent: US2011/262359 A1, 2011 ;
US 20110262359 A1
反应条件
potassium carbonate in acetonitrile
T=40°C;
参考文献
Gassiot, Amaury Cazenave; Charton, Julie; Girault-Mizzi, Sophie; Gilleron, Pauline; Debreu-Fontaine, Marie-Ange; Sergheraert, Christian; Melnyk, Patricia
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4828 - 4832
反应条件
1: CH2Cl2 / 12 h / 20 °C
2: TEA / CH2Cl2 / 2 h / 0 °C
3: K2CO3 / acetonitrile / 40 °C
View Scheme
参考文献
Gassiot, Amaury Cazenave; Charton, Julie; Girault-Mizzi, Sophie; Gilleron, Pauline; Debreu-Fontaine, Marie-Ange; Sergheraert, Christian; Melnyk, Patricia
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4828 - 4832
反应条件
1: TEA / CH2Cl2 / 2 h / 0 °C
2: K2CO3 / acetonitrile / 40 °C
View Scheme
参考文献
Gassiot, Amaury Cazenave; Charton, Julie; Girault-Mizzi, Sophie; Gilleron, Pauline; Debreu-Fontaine, Marie-Ange; Sergheraert, Christian; Melnyk, Patricia
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4828 - 4832
反应条件
1.1: methanol / 20 °C / Molecular sieve
1.2: 16 h / -10 - 20 °C
2.1: triethylamine / chloroform / 16 h / 5 - 20 °C / Sealed tube
View Scheme
参考文献
Jenkins, Thomas E.; Husfeld, Craig O.; Seroogy, Julie D.; Wray, Jonathan W.
Patent: US2011/262355 A1, 2011 ;
