反应条件
1: 5-methyl-2,4(1H,3H)-pyrimidinedione With N,O-bis-(trimethylsilyl)-acetamide in dichloromethane
T=20°C; 0.5 h; Inert atmosphere;
2: 4-bromomethyl-fluorobenzene With tetra-(n-butyl)ammonium iodide in chlorobenzene
T=20 - 160°C; 1.66667 h; Microwave irradiationInert atmosphere;
参考文献
Tang, Jing; Maddali, Kasthuraiah; Metifiot, Mathieu; Sham, Yuk Y.; Vince, Robert; Pommier, Yves; Wang, Zhengqiang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2282 - 2292