2-氨基-6-氯-3-吡啶羧酸甲酯合成路线 （共 6 条）
反应条件
1: With sulfuric acid T=0 - 70°C; 5 h; 2: With sodium hydrogencarbonate in methanol; water
参考文献
Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki
Patent: US2009/82403 A1, 2009 ;
Location in patent: Page/Page column 74 ;
反应条件
ammonia in 1,4-dioxane T=80 - 90°C; 216 h;
参考文献
Schering Corporation
Patent: US2007/82913 A1, 2007 ;
Location in patent: Page/Page column 36 ;
US 20070082913 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 18 h; Reflux;
参考文献
UNIVERSITA' DEGLI DI PARMA; UNIVERSITY OF MARYLAND, BALTIMORE; Schwarcz, Robert; Costantino, Gabriele; Amori, Laura
Patent: US2013/289081 A1, 2013 ;
Location in patent: Paragraph 0046 ;
反应条件
trifluoroacetic acid T=20°C; 2 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; Matsunaga, Nobuyuki; Suzuki, Hideo; Asano, Kouhei; Tokuhara, Hidekazu; Yamamoto, Takeshi; Okamoto, Rei
Patent: US2013/131050 A1, 2013 ;
Location in patent: Paragraph 0498; 0499 ;
反应条件
in methanol; diethyl ether; toluene T=0°C; 0.75 h; Inert atmosphere;
参考文献
Vallerini, Gian Paolo; Amori, Laura; Beato, Claudia; Tararina, Margarita; Wang, Xiao-Dan; Schwarcz, Robert; Costantino, Gabriele
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9482 - 9495
反应条件
1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h 2: dichloromethane; N,N-dimethyl-formamide / 20 °C 3: ammonium hydroxide / 1,4-dioxane / 0.33 h / 100 °C / Sealed tube; Microwave irradiation View Scheme
