1: ethyl ethynyl ether With benzo[1,3,2]dioxaborole in tetrahydrofuran; hexane T=20 - 70°C; 3 h; 2: 2,6-diamino-5-iodo-nicotinic acid ethyl ester With sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane 7.5 h; Heating / reflux; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;

1: ethyl ethynyl ether With benzo[1,3,2]dioxaborole in tetrahydrofuran; hexane T=0 - 70°C; 3 h; 2: 2,6-diamino-5-iodo-nicotinic acid ethyl ester With sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane T=20°C; 7.5 h; Heating / reflux; 3: With hydrogenchloride in tetrahydrofuran; hexane; water T=20°C; 60 h;