water; sodium hydroxide in methanol T=20°C; 2 h; Product distribution / selectivity;

1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere 2.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere 3.1: hydrogenchloride / water; methanol / 0 - 20 °C 4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C 4.2: 1 h / 50 °C View Scheme