4-氧代-2-螺(N-叔丁基哌啶-4-基)-吡喃合成路线 （共 6 条）
反应条件
L-proline in N,N-dimethyl-formamide T=80°C; 10 h;
参考文献
Chandrasekhar; Vijeender; Venkatram Reddy
Tetrahedron Letters, 2005 , vol. 46, # 41 p. 6991 - 6993
反应条件
pyrrolidine in methanol 24 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65508 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
1: benzophenone With pyrrolidine in methanol 0.0833333 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in methanol T=85°C; 3 h;
参考文献
WO2011/11872 A1, ;
Page/Page column 49 ;
WO 2011/011872 A1
反应条件
pyrrolidine in methanol 1 h; Reflux;
参考文献
WO2010/94120 A1, ;
Page/Page column 114-115 ;
WO 2010/094120 A1
反应条件
1: With trifluoroacetic acid in dichloromethane 2: With sodium hydroxide in water pH=~ 14;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65508 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C
2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 16 h / 85 °C
View Scheme
参考文献
MERCK FROSST CANADA LTD.; LECLERC, Jean-Philippe; LI, Chun, Sing; MORADEI, Oscar, Miguel
Patent: WO2011/11872 A1, 2011 ;
WO 2011/011872 A1
