1-CBZ-2-甲基-4-哌啶酮合成路线 （共 6 条）
反应条件
acetic acid; zinc T=80°C; 12 h;
参考文献
Richards, Steven; Sorensen, Bryan; Jae, Hwan-soo; Winn, Marty; Chen, Yixian; Wang, Jiahong; Fung, Steven; Monzon, Katina; Frevert, Ernst U.; Jacobson, Peer; Sham, Hing; Link
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6241 - 6245
反应条件
1: 50 percent / tetrahydrofuran / 2 h / -25 °C 2: 80 percent / Zn; AcOH / 12 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 24 p. 6241 - 6245
反应条件
1.1: triethylamine / tetrahydrofuran / 1 h / -50 - -10 °C 1.2: 3 h / -78 - 20 °C 2.1: acetic acid / zinc / 3 h / 60 °C View Scheme
参考文献
WO2012/172449 A1, ;
WO 2012/172449 A1
反应条件
1,1-diphenyl-N,N-bis(1-phenylethyl)phosphinamine; copper(II) .beta.-naphthoate Inert atmosphere;
参考文献
Organic Letters, , vol. 14, # 7 p. 1842 - 1845
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; 12 h;
参考文献
Richards, Steven; Sorensen, Bryan; Jae, Hwan-soo; Winn, Marty; Chen, Yixian; Wang, Jiahong; Fung, Steven; Monzon, Katina; Frevert, Ernst U.; Jacobson, Peer; Sham, Hing; Link
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6241 - 6245
反应条件
hydrogen; palladium hydroxide on carbon in ethyl acetate T=20°C; 2 h;
参考文献
WO2008/45250 A1, ;
Page/Page column 29 ;
WO 2008/045250 A1
