2-(4-氯苯甲酰)苯甲酸合成路线 （共 35 条）
参考文献
American Home Products Corporation
Patent: US3994920 A1, 1976 ;
反应条件
toluene-4-sulfonic acid in toluene 4 h; Dean-StarkInert atmosphereReflux;
参考文献
Gentry, Patrick R.; Kokubo, Masaya; Bridges, Thomas M.; Kett, Nathan R.; Harp, Joel M.; Cho, Hyekyung P.; Smith, Emery; Chase, Peter; Hodder, Peter S.; Niswender, Colleen M.; Daniels, J. Scott; Conn, P. Jeffrey; Wood, Michael R.; Lindsley, Craig W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9351 - 9355
反应条件
1: calcium oxide; water / 325 °C 2: AlCl3 3: copper (I)-oxide; aqueous ammonia / 220 °C View Scheme
参考文献
Newton; Groggins
Industrial and Engineering Chemistry, 1935 , vol. 27, p. 1398
Chem. Zentralbl., 1936 , vol. 107, # I p. 4004
反应条件
1: NO2/HNO3 / Ambient temperature 2: SnCl2, aq. HCl / ethanol View Scheme
参考文献
Loynes,J.M. et al.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 691 - 694
反应条件
diphosphoric acid tetrachloride T=150°C; 1 h;
参考文献
El-Sayrafi, Sami; Rayyan, Saleh
Molecules, 2001 , vol. 6, # 3 p. 279 - 286
参考文献
Hoechster Farbw.
Patent: DE75288 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 260
反应条件
dipotassium peroxodisulfate; silver(I) acetate in acetonitrile-D3
T=130°C; Pschorr reaction; 1 h; Microwave irradiation;
参考文献
Seo, Sangwon; Slater, Mark; Greaney, Michael F.
Organic Letters, 2012 , vol. 14, # 10 p. 2650 - 2653
反应条件
1: thionyl chloride; dimethylformamide
2: water; methanol / Erhitzen des Methylamin-Salzes der 2-<4-Chlor-benzoyl>-benzoesaeure auf 180grad
View Scheme
参考文献
Graf et al.
Helvetica Chimica Acta, 1959 , vol. 42, p. 1085,1086
反应条件
1: With triethylamine in tetrahydrofuran
T=-10°C; 0.5 h;
2: With chloroformic acid ethyl ester in tetrahydrofuran
T=-10°C; 1.5 h;
参考文献
Wang, Xiao; Li, Jianzhong; Zhao, Na; Wan, Xiaobo
Organic Letters, 2011 , vol. 13, # 4 p. 709 - 711
反应条件
hydrogen; palladium on activated charcoal in methanol
T=70°C; P=15200 Torr; 12 h;
参考文献
Bayer, Ernst; Hayat, Safdar; Atta-Ur-Rahman; Choudhary, M. Iqbal; Khan, Khalid Mohammed; Shah, Syed Tasadaque Ali; Imran-Ul-Haq; Anwar, M. Usman; Voelter, Wolfgang
Arzneimittel-Forschung/Drug Research, 2005 , vol. 55, # 10 p. 588 - 597
