3-氨基-4-甲基噻吩-2-甲酸甲酯合成路线

参考文献

Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

1356016-36-8

参考文献

Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1

77-78-1硫酸二甲酯+

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

175137-10-73-二甲基氨基-4-甲基-2-羧酸甲酯

参考文献

WO2004/39795 A2, ;

Page 271 ;
WO 2004/039795 A2

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

1269667-57-3

参考文献

HANMI SCIENCE CO., LTD.; CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; Son, Jung Beom; Jung, Seung Hyun; Choi, Wha ll; Jung, Young Hee; Choi, Jae Yul; Song, Ji Yeon; Lee, Kyu Hang; Lee, Jae Chul; Kim, Eun Young; Ahn, Young Gil; Kim, Maeng Sup; Choi, Hwan Geun; Sim, Tae Bo; Ham, Young Jin; Park, Dong-sik; Kim, Hwan; Kim, Dong-Wook
Patent: US2013/53370 A1, 2013 ;

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

229342-86-33-氯-4-甲基-2-硫代苯羧酸

参考文献

Kochanny, Monica J.; Adler, Marc; Ewing, Janice; Griedel, Brian D.; Ho, Elena; Karanjawala, Rushad; Lee, Wheeseong; Lentz, Dao; Liang, Amy M.; Morrissey, Michael M.; Phillips, Gary B.; Post, Joseph; Sacchi, Karna L.; Sakata, Steven T.; Subramanyam, Babu; Vergona, Ron; Walters, Janette; White, Kathy A.; Whitlow, Marc; Ye, Bin; Zhao, Zuchun; Shaw, Kenneth J.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2127 - 2146

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

175137-21-04-氯-7-甲基噻吩并[3,2-D]嘧啶

参考文献

CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; ALVAREZ ESCOBAR, Rosa Maria; RIESCO FAGUNDO, Rosario Concepcion; GARCIA GARCIA, Ana Belen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; BLANCO APARICIO, Carmen; CEBRIAN MUNOZ, David Alvaro
Patent: WO2012/156756 A2, 2012 ;
WO 2012/156756 A2

77287-34-4甲亚胺酸+

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

175137-13-07-甲基噻吩并[3,2-D]嘧啶-4(3H)-酮

参考文献

HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 62 ;

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

175137-13-07-甲基噻吩并[3,2-D]嘧啶-4(3H)-酮

参考文献

CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; ALVAREZ ESCOBAR, Rosa Maria; RIESCO FAGUNDO, Rosario Concepcion; GARCIA GARCIA, Ana Belen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; BLANCO APARICIO, Carmen; CEBRIAN MUNOZ, David Alvaro
Patent: WO2012/156756 A2, 2012 ;
WO 2012/156756 A2

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

23967-97-7

参考文献

SANOFI-AVENTIS U.S. LLC; AYERS, Timothy, A.; FERRO, Michael; POWERS, Matthew R.; CHANDRAMOULI, Sithamalli V.; LI, XiaoJie; SHAY, JR., John J.; HILLEGASS, Andrea
Patent: WO2011/19784 A1, 2011 ;
Location in patent: Page/Page column 6-7 ;

85006-31-13-氨基-4-甲基噻吩-2-甲酸甲酯

175137-11-8

参考文献

Kochanny, Monica J.; Adler, Marc; Ewing, Janice; Griedel, Brian D.; Ho, Elena; Karanjawala, Rushad; Lee, Wheeseong; Lentz, Dao; Liang, Amy M.; Morrissey, Michael M.; Phillips, Gary B.; Post, Joseph; Sacchi, Karna L.; Sakata, Steven T.; Subramanyam, Babu; Vergona, Ron; Walters, Janette; White, Kathy A.; Whitlow, Marc; Ye, Bin; Zhao, Zuchun; Shaw, Kenneth J.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2127 - 2146