(S)-3-(二甲基氨基)-1-(3-甲氧基苯基)-2-甲基-1-丙酮合成路线 （共 5 条）
反应条件
diethylamine in tert-butyl methyl ether T=20 - 25°C; 1.5 h;
参考文献
GRUeNENTHAL GMBH
Patent: WO2008/12047 A1, 2008 ;
Location in patent: Page/Page column 19-20 ;
反应条件
1: acetone; methanol 2: diethylamine / tert-butyl methyl ether View Scheme
反应条件
1: trifluoroacetic acid 2: acetone; methanol 3: diethylamine / tert-butyl methyl ether View Scheme
反应条件
1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 3.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethanol; water / 20 °C / Inert atmosphere View Scheme
参考文献
Shire Pharmaceuticals, Inc.
Patent: US2011/190267 A1, 2011 ;
反应条件
1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 3.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethanol; water / 20 °C / Inert atmosphere 4.1: methanesulfonic acid; dl-methionine / 72 h / 80 °C 4.2: pH 10 - 12 View Scheme
