5-溴-4-甲氧基-1H-吲唑合成路线 （共 3 条）
反应条件
1: With N-methoxyamine hydrochloride; potassium carbonate in ethylene glycol dimethyl ether T=20°C; 5 h; 2: With hydrazine in ethylene glycol dimethyl ether T=100°C; 16 h;
参考文献
WO2008/107455 A1, ;
Page/Page column 25 ;
WO 2008/107455 A1
反应条件
1: With potassium carbonate in ethylene glycol dimethyl ether T=20°C; 4 h; Inert atmosphere; 2: With hydrazine hydrate in ethylene glycol dimethyl ether T=100°C; 16 h; Inert atmosphere;
参考文献
SERAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; GOVEK, Steven, P.; KAHRAMAN, Mehmet; JULIEN, Jackaline, D.; NAGASAWA, Johnny, Y.; DOUGLAS, Karensa, L.; BONNEFOUS, Celine; LAI, Andiliy, G.
Patent: WO2013/142266 A1, 2013 ;
Location in patent: Paragraph 00492 ;
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.25 h / -78 °C / |Inert atmosphere 1.2: 0.83 h / -78 °C / |Inert atmosphere 2.1: potassium carbonate / ethylene glycol dimethyl ether / 4 h / 20 °C / |Inert atmosphere 2.2: 16 h / 100 °C / |Inert atmosphere View Scheme
