3,5-双(三氟甲基)苄胺合成路线 （共 7 条）
反应条件
ammonia; hydrogen; nickel in ethanol T=40 - 70°C; P=67506.8 Torr; 1.5 h;
参考文献
EP1500641 A1, ;
Page 12 ;
反应条件
water; hydrogen; palladium on activated charcoal in methanol T=60°C; P=3750.3 Torr; 12 h;
参考文献
Organic Letters, , vol. 5, # 7 p. 1007 - 1010
反应条件
hydrogen; silica gel; nickel in ammonia; isopropyl alcohol T=120°C; P=7600 Torr; 2 h;
参考文献
Synlett, , # 10 p. 1623 - 1625
反应条件
hydrogenchloride in methanol
反应条件
1: sodium borohydride / methanol 2: 100 percent / hydrogen; water / 5 percent Pd/C NX-type / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Organic Letters, , vol. 5, # 7 p. 1007 - 1010
反应条件
1: 3,5-bis-(trifluoromethyl)-benzylamine With trimethylaluminum in dichloromethane; toluene
T=20°C; 0.333333 h;
2: 9-phenylfuro[3,4-b]quinoline-1(3H)-one in dichloromethane; toluene
Heating;
参考文献
Cappelli, Andrea; Giuliani, Germano; Mohr, Galla Pericot; Gallelli, Andrea; Anzini, Maurizio; Vomero, Salvatore; Cupello, Aroldo; Scarrone, Simona; Matarrese, Mario; Moresco, Rosa Maria; Fazio, Ferruccio; Finetti, Federica; Morbidelli, Lucia; Ziche, Marina
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1315 - 1318
