反应条件
1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C / |Inert atmosphere
2: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 0.5 h / |Inert atmosphere; |Reflux
4: borane-THF / tetrahydrofuran / 2 h / |Inert atmosphere; |Reflux
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参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; WANG, Zhanguo; ZHOU, Mingwei
Patent: WO2013/79452 A1, 2013 ;