1: 2-ethoxycarbonylacetyl chloride; Ethyl 2-[(3-methylbutyl)amino]-3-pyridinecarboxylate in dichloromethane T=20°C; 1 h; 2: With triethylamine in dichloromethane 3: 2-ethoxycarbonylacetyl chloride With hydrogenchloride; sodium ethanolate; sodium hydrogencarbonate more than 3 stages;

sodium hydride in N,N-dimethyl acetamide T=120°C; 2 h;