4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 24 h;

1: (3R)-3-hydroxypyrrolidine hydrochloride With sodium t-butanolate in toluene T=20°C; 0.5 h; 2: 3-fluoro-1-bromobenzene With 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in toluene T=90°C; 3 h;