1: With potassium tert-butylate in tetrahydrofuran; dimethyl sulfoxide T=65 - 70°C; 4.25 h; 2: With sulfuric acid; water in toluene T=20°C; 1 h; 3: With sodium hydroxide in water; toluene pH=8.0 - 12.7; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO.KG
Patent: WO2005/37831 A1, 2005 ;
Location in patent: Page/Page column 12-13 ;