potassium carbonate in tetrahydrofuran T=62°C; 17 h;

1: 6-[[(tert-butoxy)carbonyl]amino]-2-[[(4-fluoro-1,3-dihydro-2H-isoindol-2-yl)carbonyl]oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-hexadecahydro-5,16-dioxo-(2R,6S,12Z,13aS,14aR,16aS)-cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid With acetic anhydride; sodium carbonate in tetrahydrofuran T=45°C; 8.5 h; 2: cyclopropanesulfonic acid amide With potassium carbonate in tetrahydrofuran T=62°C; 17 h;