5-(2-溴-乙酰基)-1,3-二氢-异吲哚-2-羧酸叔丁酯合成路线 (共 2 条)
反应条件
1: With chloro-trimethyl-silane; lithium hexamethyldisilazane in tetrahydrofuran
T=-78 - 0°C; 0.5 h;
2: With phenyltrimethylammonium tribromide in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
INTERMUNE, INC.; ARRAY BIOPHARMA INC.
Patent: WO2005/37214 A2, 2005 ;
Location in patent: Page/Page column 218-219 ;
反应条件
sodium carbonate in ethanol
0.5 h; Heating / reflux;
参考文献
INTERMUNE, INC.; ARRAY BIOPHARMA INC.
Patent: WO2005/37214 A2, 2005 ;
Location in patent: Page/Page column 218-219 ;