4-(4-氟苯基)-7-羟基-2H-1-苯并吡喃-2-酮合成路线 (共 2 条)
反应条件
hydrogenchloride in methanol T=0 - 20°C; Pechmann condensation; 15 h;
参考文献
Grimm, Erich L.; Brideau, Christine; Chauret, Nathalie; Chan, Chi-Chung; Delorme, Daniel; Ducharme, Yves; Ethier, Diane; Falgueyret, Jean-Pierre; Friesen, Richard W.; Guay, Jocelyne; Hamel, Pierre; Riendeau, Denis; Soucy-Breau, Chantal; Tagari, Philip; Girard, Yves
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2528 - 2531
反应条件
methanesulfonic acid T=40°C; Pechmann condensation; 0.25 h; Inert atmosphereLarge scale reaction;
参考文献
Gosselin, Francis; Britton, Robert A.; Davies, Ian W.; Dolman, Sarah J.; Gauvreau, Danny; Hoerrner, R. Scott; Hughes, Gregory; Janey, Jacob; Lau, Stephen; Molinaro, Carmela; Nadeau, Christian; Oshea, Paul D.; Palucki, Michael; Sidler, Rick
Journal of Organic Chemistry, 2010 , vol. 75, # 12 p. 4154 - 4160